Endocrine Abstracts

Background: Hypoglycaemia, possibly due to non-physiological hormone replacement, and poor cardiovascular outcomes are described in patients with adrenal insufficiency (AI), particularly in the adult population. In this study, we describe glucose profiles and risk factors for premature cardiovascular disease (CVD) in children with secondary AI (SAI).Methods: Participants underwent continuous glucose monitoring (CGM), for seven days (blinded Dexcom G6 mon...

Background: Increased hair cortisol concentrations are reported in Turner Syndrome (TS) patients compared to healthy controls (HC).(1) Increased cortisol exposure could contribute to cardiovascular, metabolic and bone morbidity in TS. Hair cortisol concentrations give no information about the circadian profile of cortisol, which is important for cardiovascular health. Cortisol is inactivated to cortisone by 11β hydroxysteroid dehydrogenase (11βHSD) type-2 and regener...

Background: Thyroid cancer is the most common endocrine malignancy, and papillary thyroid carcinoma (PTC) is the most frequent type of thyroid malignancy. Although the mortality rate is low, some patients experience cancer recurrence during follow-up periods. Early detection of recurrence helps improve the outcomes of patients and reduce the socioeconomic burden. In this study, we investigated the accuracy of a novel multi-modal prediction model by simultaneously analyzing num...

Section 1&2: Case history and investigations: We report the case of a 52-year-old man with recurrent immunodeficiency-related Burkitt’s lymphoma. 11 years following remission of his disease he presented with a firm lump in the parotid region. A biopsy showed histopathological evidence of a relapse. An 18F FDG PET was undertaken to determine the extent of the disease and response to R-DHAX chemotherapy. Areas of high uptake were identified in both sides of t...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder with a prevalence of 0.86% in Europe. Approximately 10% of cases are hereditary. Syndromic PHPT occurs as part of multiple endocrine neoplasia (MEN)1, MEN4, MEN2A and hyperparathyroidism jaw tumour syndrome. Non-syndromic causes include familial hypocalciuric hypercalcaemia. Establishing the underlying genetic cause allows for targeted, cost effective management. Current guidelines recommend that genetic testing...

The present study investigated the vasorelaxant effects of sitagliptin, which is a dipeptidyl peptidase-4 (DPP-4) inhibitor in aortic rings pre-contracted with phenylephrine (Phe). Sitagliptin induced vasorelaxation in a concentration-dependent manner but the inhibition of voltage-dependent K+ (Kv) channels by pretreatment with 4-aminopyridine (4-AP) effectively reduced this effect. By contrast, the inhibition of inward rectifier K+ (Kir) channels by pret...

In this study, we used the phenylephrine-precontracted aortic ring preparation to investigate the mechanisms underlying the vasorelaxant effect of linagliptin. We found that linagliptin induced vasorelaxation in a dose-dependent manner. The vasorelaxant effect of linagliptin was not changed by the removal of the endothelium, or by pre-treatment with a NO synthase inhibitor (L-NAME) or a small-conductance Ca2+-dependent K+ channel inhibitor (apamin). Moreo...

The vasodilatory effects of the meglitinide class of anti-diabetic drug, mitiglinide in phenylephrine (Phe)-pre-contracted aortic rings were investigated. Mitiglinide concentration-dependently induced vasodilation. Administration of the large-conductance Ca2+-dependent K+ (BKCa) channel inhibitor paxilline, inward rectifier K+ (Kir) channel inhibitor Ba2+, and ATP-dependent K+ (KATP) channel inhibitor...

In this study, we explored vildagliptin-induced vasorelaxation and its related signaling mechanisms using phenylephrine induced pre-contracted rabbit aortic rings. Vildagliptin induced vasorelaxation in a dose-dependent fashion. Pre-treatment with the large-conductance Ca2+-dependent K+ channel inhibitor paxilline, ATP-dependent K+ channel inhibitor glibenclamide and inward rectifier K+ channel inhibitor Ba2+ did not chang...

Introduction: Evidence is currently limited regarding the management of abnormal lipid profiles in children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM). ISPAD recommend monitoring every five years and statin use to maintain LDL cholesterol <3.4 mmol/L1. Guidance is specific to LDL. NICE guidelines do no recommend routine screening for CYP with T1DM.Methodology: We reviewed all lipid profiles (including cholesterol, triglyce...